Last update
3/24/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.8
USERS' SCORE
Moderately Good
Based on 11 Reviews
7.5
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Calcium (elemental) (from 2,775 mg complex of Calcium Carbonate, Calcium Citrate, Calcium Ascorbate)
1 g (1,000 mg)
77%
Magnesium (elemental) (from 928 mg complex of Magnesium Oxide, Magnesium Citrate, Magnesium Ascorbate)
500 mg
119%
Top Medical Research Studies
9
Magnesium sulfate alleviates postoperative pain
We explored the impact of magnesium sulfate on managing pain following total knee arthroplasty. In a randomized, double-blind trial with 90 patients, half received a blend of analgesics that included magnesium sulfate, while the other half did not.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Overall, adding magnesium sulfate appears beneficial for postoperative knee pain management.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Overall, adding magnesium sulfate appears beneficial for postoperative knee pain management.
Read More
9
Magnesium aids postoperative pain relief
We explored the role of magnesium in reducing knee pain following total knee arthroplasty (TKA). In a study involving 119 adults, participants received either an adductor canal block with magnesium and bupivacaine or just bupivacaine.
Those who received magnesium reported significantly lower pain scores and reduced opioid usage in the days after surgery, without experiencing an uptick in nausea or dissatisfaction. This suggests that adding magnesium to local anesthesia could enhance pain management for TKA patients, promoting a smoother recovery.
Those who received magnesium reported significantly lower pain scores and reduced opioid usage in the days after surgery, without experiencing an uptick in nausea or dissatisfaction. This suggests that adding magnesium to local anesthesia could enhance pain management for TKA patients, promoting a smoother recovery.
Read More
9
Magnesium reduces postoperative knee pain
We evaluated the impact of magnesium sulphate on pain levels for 44 patients undergoing staged bilateral total knee arthroplasty.
In this study, the magnesium group received magnesium sulphate while the control group received isotonic saline during their surgeries.
Our findings showed that those who received magnesium experienced significantly lower pain scores compared to the control group, both after their first and second surgeries.
Importantly, magnesium also helped reduce the need for additional pain relief medications in the days following surgery.
In this study, the magnesium group received magnesium sulphate while the control group received isotonic saline during their surgeries.
Our findings showed that those who received magnesium experienced significantly lower pain scores compared to the control group, both after their first and second surgeries.
Importantly, magnesium also helped reduce the need for additional pain relief medications in the days following surgery.
Read More
Most Useful Reviews
7.5
Reduced knee pain
74 people found this helpful
Very cool! Calcium and magnesium work well together. I discovered that taking these in the evening allows for better absorption. The jar is large, and the tablets are sizeable. I've noticed significant relief; my knee pain has decreased, and osteochondrosis is less concerning. I prefer to take them in a course.
Read More
9
Knee and teeth health
1 people found this helpful
An excellent combination of active ingredients. My knees stopped aching and my teeth stopped crumbling.
Read More
9
Knee pain relief
I bought calcium as I train regularly at the gym. After using it for two months, my knee pain has significantly reduced.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.8
- All Researches
9
We explored how calcium phosphate (CaP) injections impact knee pain, particularly in patients suffering from osteoarthritis-related bone marrow lesions (OA-BML). In this study, we compared two groups of patients: those who received knee arthroscopy combined with CaP injections and those who had knee arthroscopy for different knee issues.
Our observations showed that patients receiving the CaP injections experienced less frequent conversions to total knee arthroplasty (TKA) when compared to the other group. Notably, within the CaP group, we noticed a significant improvement in their knee injury and functional outcome scores before and after the procedure. However, patients who only underwent knee arthroscopy did not show the same level of improvement.
Overall, we found that adding CaP injections during knee surgery for OA-BML significantly enhanced functional outcomes over traditional surgery alone. This study underscores the potential benefits of CaP treatments in managing knee pain and improving quality of life for those suffering from knee OA.
Our observations showed that patients receiving the CaP injections experienced less frequent conversions to total knee arthroplasty (TKA) when compared to the other group. Notably, within the CaP group, we noticed a significant improvement in their knee injury and functional outcome scores before and after the procedure. However, patients who only underwent knee arthroscopy did not show the same level of improvement.
Overall, we found that adding CaP injections during knee surgery for OA-BML significantly enhanced functional outcomes over traditional surgery alone. This study underscores the potential benefits of CaP treatments in managing knee pain and improving quality of life for those suffering from knee OA.
Read More
9
Magnesium sulfate alleviates postoperative pain
We explored the impact of magnesium sulfate on managing pain following total knee arthroplasty. In a randomized, double-blind trial with 90 patients, half received a blend of analgesics that included magnesium sulfate, while the other half did not.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Overall, adding magnesium sulfate appears beneficial for postoperative knee pain management.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Overall, adding magnesium sulfate appears beneficial for postoperative knee pain management.
Read More
9
Magnesium aids postoperative pain relief
We explored the role of magnesium in reducing knee pain following total knee arthroplasty (TKA). In a study involving 119 adults, participants received either an adductor canal block with magnesium and bupivacaine or just bupivacaine.
Those who received magnesium reported significantly lower pain scores and reduced opioid usage in the days after surgery, without experiencing an uptick in nausea or dissatisfaction. This suggests that adding magnesium to local anesthesia could enhance pain management for TKA patients, promoting a smoother recovery.
Those who received magnesium reported significantly lower pain scores and reduced opioid usage in the days after surgery, without experiencing an uptick in nausea or dissatisfaction. This suggests that adding magnesium to local anesthesia could enhance pain management for TKA patients, promoting a smoother recovery.
Read More
9
We evaluated how effective magnesium, especially when combined with bupivacaine, is for managing knee pain after arthroscopy. Our study looked at data from 78 randomized trials involving 4,425 participants.
It turns out that magnesium with bupivacaine is the top performer in easing pain right after surgery and at the 24-hour mark, outperforming other analgesics like morphine.
However, magnesium alone didn’t show significant pain relief. We found that using this combination does not lead to more side effects, making it a safe choice for recovery.
It turns out that magnesium with bupivacaine is the top performer in easing pain right after surgery and at the 24-hour mark, outperforming other analgesics like morphine.
However, magnesium alone didn’t show significant pain relief. We found that using this combination does not lead to more side effects, making it a safe choice for recovery.
Read More
9
Magnesium reduces postoperative knee pain
We evaluated the impact of magnesium sulphate on pain levels for 44 patients undergoing staged bilateral total knee arthroplasty.
In this study, the magnesium group received magnesium sulphate while the control group received isotonic saline during their surgeries.
Our findings showed that those who received magnesium experienced significantly lower pain scores compared to the control group, both after their first and second surgeries.
Importantly, magnesium also helped reduce the need for additional pain relief medications in the days following surgery.
In this study, the magnesium group received magnesium sulphate while the control group received isotonic saline during their surgeries.
Our findings showed that those who received magnesium experienced significantly lower pain scores compared to the control group, both after their first and second surgeries.
Importantly, magnesium also helped reduce the need for additional pain relief medications in the days following surgery.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 11 Reviews
7.5
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Reduced knee pain
74 people found this helpful
Very cool! Calcium and magnesium work well together. I discovered that taking these in the evening allows for better absorption. The jar is large, and the tablets are sizeable. I've noticed significant relief; my knee pain has decreased, and osteochondrosis is less concerning. I prefer to take them in a course.
Read More
9
Knee and teeth health
1 people found this helpful
An excellent combination of active ingredients. My knees stopped aching and my teeth stopped crumbling.
Read More
9
Knee pain relief
I bought calcium as I train regularly at the gym. After using it for two months, my knee pain has significantly reduced.
Read More
9
Quick knee recovery
After an injury and surgery on my left knee, my doctor prescribed this supplement. It has been highly effective, aiding my recovery and improving my knee pain and mobility. I feel much calmer overall.
Read More
7.5
Joint improvement noted
29 people found this helpful
I recall when I was pregnant and my doctor recommended these. I noticed a positive change in my joints; my knee pain reduced. My nails grew longer, and my hair thickened, ceasing to fall out. This supplement is excellent, illuminating my experience.
Read More
Frequently Asked Questions
0
Knees hurt
2 people found this helpful
This form of calcium did not suit me; my knee pain increased. However, the same brand of Calcium Citrate worked well for me. If my review was helpful, please give it a thumbs up.
7.5
Reduced knee pain
74 people found this helpful
Very cool! Calcium and magnesium work well together. I discovered that taking these in the evening allows for better absorption. The jar is large, and the tablets are sizeable. I've noticed significant relief; my knee pain has decreased, and osteochondrosis is less concerning. I prefer to take them in a course.
9
Magnesium sulfate alleviates postoperative pain
We explored the impact of magnesium sulfate on managing pain following total knee arthroplasty. In a randomized, double-blind trial with 90 patients, half received a blend of analgesics that included magnesium sulfate, while the other half did not.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Overall, adding magnesium sulfate appears beneficial for postoperative knee pain management.
Following surgery, the results showed that magnesium sulfate helped prolong pain relief and reduced the need for opioids. Patients receiving it experienced less postoperative pain and moved towards recovery more effectively.
Overall, adding magnesium sulfate appears beneficial for postoperative knee pain management.
7
Magnesium aids knee surgery recovery
We investigated how magnesium sulfate influences recovery after knee surgery. In our study, 148 elderly patients undergoing total knee arthroplasty were divided into two groups: one received magnesium sulfate, while the other received a saline solution.
This double-blind setup allowed us to see if magnesium sulfate could enhance recovery quality after surgery. Our findings indicate that magnesium sulfate does help reduce early postoperative pain and improves overall recovery in these patients.
Overall, magnesium sulfate appears beneficial in managing pain during the recovery process.
This double-blind setup allowed us to see if magnesium sulfate could enhance recovery quality after surgery. Our findings indicate that magnesium sulfate does help reduce early postoperative pain and improves overall recovery in these patients.
Overall, magnesium sulfate appears beneficial in managing pain during the recovery process.
9
We looked into how magnesium can help ease knee pain after total knee arthroplasty. In a study of 80 patients, those who received an injection of magnesium sulfate and ropivacaine experienced significantly less pain and needed less morphine compared to those who got a saline injection. This approach not only reduced morphine use in the first 48 hours but also allowed patients to regain movement quicker. Overall, our findings suggest that magnesium may be a beneficial part of pain management in knee surgery.
8
We examined the impact of magnesium sulfate paired with levobupivacaine on pain relief after total knee arthroplasty (TKA). In our study, 60 patients were divided into two groups: one received the magnesium cocktail, while the other only got levobupivacaine. Our findings revealed that the magnesium group experienced prolonged pain relief, reduced reliance on additional pain medication, and effective management of early postoperative pain. Overall, this suggests that magnesium sulfate could be a valuable addition to pain management protocols following knee surgery.
7
Magnesium improves knee pain management
We investigated the use of magnesium combined with levobupivacaine in patients undergoing ACL reconstruction. In this study, 107 patients were divided into two groups: one receiving just levobupivacaine and the other receiving levobupivacaine with magnesium.
Our findings showed that adding magnesium improved pain relief and satisfaction, but it also delayed when patients could first move after surgery. Overall, magnesium seems to offer better quality pain control, while also reducing the need for additional pain relief medications.
Our findings showed that adding magnesium improved pain relief and satisfaction, but it also delayed when patients could first move after surgery. Overall, magnesium seems to offer better quality pain control, while also reducing the need for additional pain relief medications.
4
We explored the role of calcium gluconate as an activator alongside platelet-rich plasma (PRP) injections for patients dealing with early knee osteoarthritis. In this study, participants were split into two groups: one received PRP alone, while the other got PRP mixed with calcium gluconate.
Both groups were evaluated over six months for pain relief and overall satisfaction. Interestingly, despite a noticeable decrease in pain and improvement in overall function in both groups, we found no significant differences when comparing the effectiveness of the two treatments.
This led us to conclude that adding calcium gluconate might not provide any extra benefit to PRP injections in managing knee pain for early-stage osteoarthritis, which is quite important for patients considering their treatment options.
Both groups were evaluated over six months for pain relief and overall satisfaction. Interestingly, despite a noticeable decrease in pain and improvement in overall function in both groups, we found no significant differences when comparing the effectiveness of the two treatments.
This led us to conclude that adding calcium gluconate might not provide any extra benefit to PRP injections in managing knee pain for early-stage osteoarthritis, which is quite important for patients considering their treatment options.
9
We explored how calcium phosphate (CaP) injections impact knee pain, particularly in patients suffering from osteoarthritis-related bone marrow lesions (OA-BML). In this study, we compared two groups of patients: those who received knee arthroscopy combined with CaP injections and those who had knee arthroscopy for different knee issues.
Our observations showed that patients receiving the CaP injections experienced less frequent conversions to total knee arthroplasty (TKA) when compared to the other group. Notably, within the CaP group, we noticed a significant improvement in their knee injury and functional outcome scores before and after the procedure. However, patients who only underwent knee arthroscopy did not show the same level of improvement.
Overall, we found that adding CaP injections during knee surgery for OA-BML significantly enhanced functional outcomes over traditional surgery alone. This study underscores the potential benefits of CaP treatments in managing knee pain and improving quality of life for those suffering from knee OA.
Our observations showed that patients receiving the CaP injections experienced less frequent conversions to total knee arthroplasty (TKA) when compared to the other group. Notably, within the CaP group, we noticed a significant improvement in their knee injury and functional outcome scores before and after the procedure. However, patients who only underwent knee arthroscopy did not show the same level of improvement.
Overall, we found that adding CaP injections during knee surgery for OA-BML significantly enhanced functional outcomes over traditional surgery alone. This study underscores the potential benefits of CaP treatments in managing knee pain and improving quality of life for those suffering from knee OA.
References
- Rai S, Patel S, Chouhan DK, Jain A, Thami T, et al. Is There a Need for an Exogenous Activator Along with PRP for Early Knee Osteoarthritis? A Triple-Blinded Randomized Control Trial. Indian J Orthop. 2024;58:905. 10.1007/s43465-024-01159-7
- Stratton A, Wanless M, Abidi N. Total Knee Conversion Rates and Functional Outcome After Calcium Phosphate Injection for Bone Marrow Lesions of the Knee. J Knee Surg. 2024;37:341. 10.1055/a-2094-5724
- Zhu Y, Shen S, Cui L, Wu L, Zhang B. Magnesium sulphate and sodium bicarbonate as additives for periarticular local infiltration analgesia improve pain management after unicompartmental knee arthroplasty: a prospective, double-blind, randomized controlled trial. J Orthop Surg Res. 2024;19:764. 10.1186/s13018-024-05233-6
- Xu H, Hao C, Wang X, Du J, Zhang T, et al. Effect of Magnesium Sulfate Infusion on Postoperative Quality of Recovery in Patients Undergoing Total Knee Arthroplasty: A Prospective, Double-Blind, Randomized Controlled Trial. Drug Des Devel Ther. 2024;18:919. 10.2147/DDDT.S444896
- Zhao C, Wang L, Chen L, Wang Q, Kang P. Effects of magnesium sulfate on periarticular infiltration analgesia in total knee arthroplasty: a prospective, double-blind, randomized controlled trial. J Orthop Surg Res. 2023;18:301. 10.1186/s13018-023-03790-w
- Wang Q, Zhao C, Hu J, Ma T, Yang J, et al. Efficacy of a Modified Cocktail for Periarticular Local Infiltration Analgesia in Total Knee Arthroplasty: A Prospective, Double-Blinded, Randomized Controlled Trial. J Bone Joint Surg Am. 2023;105:354. 10.2106/JBJS.22.00614
- Choi JW, Lahori A, Merlo JA, Gill O, Ghoddoussi F, et al. Adductor Canal Blocks With Bupivacaine and Magnesium After Same-day Discharge Total Knee Arthroplasty Improve Postoperative Pain Relief and Decrease Opioid Consumption: A Prospective Randomized Controlled Trial. Clin J Pain. 2022;38:388. 10.1097/AJP.0000000000001036
- He Y, He H, Li X, Lei G, Xie D, et al. Intra-Articular Magnesium Plus Bupivacaine Is the Most Effective and Safe Postoperative Analgesic Option Following Knee Arthroscopy: A Network Meta-analysis. Arthroscopy. 2022;38:2897. 10.1016/j.arthro.2022.03.013
- Shi L, Zhu H, Ma J, Shi LL, Gao F, et al. Intra-articular magnesium to alleviate postoperative pain after arthroscopic knee surgery: a meta-analysis of randomized controlled trials. J Orthop Surg Res. 2021;16:111. 10.1186/s13018-021-02264-1
- Zhao Z, Zhang X, Peng H, Li W, Liu H, et al. Magnesium Sulfate Combined with a Levobupivacaine Periarticular Cocktail for Analgesia in the Early Postoperative Period after Total Knee Arthroplasty. J Knee Surg. 2021;34:1463. 10.1055/s-0040-1710364
- Condello V, Filardo G, Madonna V, Andriolo L, Screpis D, et al. Use of a Biomimetic Scaffold for the Treatment of Osteochondral Lesions in Early Osteoarthritis. Biomed Res Int. 2018;2018:7937089. 10.1155/2018/7937089
- Shmagel A, Onizuka N, Langsetmo L, Vo T, Foley R, et al. Low magnesium intake is associated with increased knee pain in subjects with radiographic knee osteoarthritis: data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2018;26:651. 10.1016/j.joca.2018.02.002
- Shin HJ, Kim EY, Na HS, Kim TK, Kim MH, et al. Magnesium sulphate attenuates acute postoperative pain and increased pain intensity after surgical injury in staged bilateral total knee arthroplasty: a randomized, double-blinded, placebo-controlled trial. Br J Anaesth. 2016;117:497. 10.1093/bja/aew227
- Chen Y, Zhang Y, Zhu YL, Fu PL. Efficacy and safety of an intra-operative intra-articular magnesium/ropivacaine injection for pain control following total knee arthroplasty. J Int Med Res. 2012;40:2032. PubMed
- Ekmekci P, Bengisun ZK, Akan B, Kazbek BK, Ozkan KS, et al. The effect of magnesium added to levobupivacaine for femoral nerve block on postoperative analgesia in patients undergoing ACL reconstruction. Knee Surg Sports Traumatol Arthrosc. 2013;21:1119. 10.1007/s00167-012-2093-4
- Koltka K, Koknel-Talu G, Asik M, Ozyalcin S. Comparison of efficacy of intraarticular application of magnesium, levobupivacaine and lornoxicam with placebo in arthroscopic surgery. Knee Surg Sports Traumatol Arthrosc. 2011;19:1884. 10.1007/s00167-011-1497-x
- Chen Y, Zhang Y, Zhu YL, Fu PL. Efficacy and safety of an intra-operative intra-articular magnesium/ropivacaine injection for pain control following total knee arthroplasty. J Int Med Res. 2009;37:1733. PubMed
- Farouk S, Aly A. A comparison of intra-articular magnesium and/or morphine with bupivacaine for postoperative analgesia after arthroscopic knee surgery. J Anesth. 2009;23:508. 10.1007/s00540-009-0822-8
Data last updated:
